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By contrast, in p21 KO cells, nutlin-3 treatment resulted in the differential expression of even more genes than observed in Control cells, consistent with the notion that p21 is itself an important transcriptional regulator (Fig 3A) (Delavaine & La Thangue, 1999

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Signs and symptoms: Many common symptoms can be caused by vitamin B12 deficiency, including weakness, tiredness, lightheadedness, heart palpitations, shortness of breath, pallor (pale skin), diarrhea, decreased appetite, nerve problems like numbness or tingling, visual changes and psycho-emotional problems like depression, memory loss or behavioral changes